长必安对结肠癌肝转移的干预作用

CHANG BI AN Co.Interventional Effect on Colorectal Cancer with Liver Metastasis

[目的]研究中药复方长必安胶囊对结肠癌肝转移的影响。[方法]用肠壁原位接种技术和脾脏切除法建立人肠癌裸鼠转移模型。模型动物分3组 ,每组15只。分别予高浓度长必安浸膏液(治疗Ⅰ组 )、低浓度长必安浸膏液 (治疗Ⅱ组 )、生理盐水 (对照组 ) ,比较各组抑瘤率及肝转移率。[结果]治疗Ⅰ组和Ⅱ组的抑瘤率分别达到23.1 %和16.7%治疗 ,Ⅰ组和Ⅱ组及对照组的肝转移率 ,分别为60.0%和73.3%及93.3%。

To study the influence of TCM CHANG BI AN Co.on coloretal cancer liver metastasis.Forty_five nude mice model of colorectal cancer liver metastasis was established by anastomotic orthotopic transplantation and splenectomy technique.Mice were randomly divided into 3 groups:Treatment group Ⅰ high concentration CHANG BI AN fluidextractum,treatment group Ⅱlow concentration CHANG BI AN fluidextractum and control group given saline solution.The differences of liver metastasis between the groups were compared.The tumor in inhibited rates in group Ⅰand group Ⅱ were 23.1% and 16.% respectively .The incidence of liver metastasis in group Ⅰ,groupⅡ and control group were 60.8%,73.3% and 93.3% respectively(P<0.05).[Conclusion]CHANG BI AN reduces colorectal cancer liver metastasis in certain degress.