乙醛脱氢酶2基因多态性与食管癌易感性的关系

Polymorphisms of Aldehyde Dehydrogenase-2 Genotypes and the Risk of Esophageal Cancer

[目的]研究乙醛脱氢酶2(ALDH2)基因多态性和饮酒习惯与食管癌易感性间的相互关系。[方法]在江苏泰兴市选择食管癌新发病例98例和正常对照273例进行流行病学调查研究 ,并用PCR RFLP方法检测研究对象的ALDH2基因型。应用EpiInfo统计软件包 ,分析了男性食管癌组和男性对照组间不同饮酒习惯、ALDH2基因多态性与食管癌易感性的关系。[结果]食管癌组和对照组ALDH2变异基因型携带者分别占43.88%和47.25% ,两者间的差异无显著性。饮酒频度每周<3次的男性ALDH 1基因型携带者与每周≥3次男性ALDH 1 *2/ALDH 2 基因型携带者间 ,经统计学分析病例组与对照组间存在显著性的差异。

To explore the relationship between polymorphisms of aldehyde dehydrogenase 2 genotypes and susceptibility of esophageal cancer.We conducted a case control study with 98 cases of esophageal cancer and 273 population based controls in Taixing city of Jiangsu province,China.The epidemiological data were collected,and DNA of peripheral blood leukocytes was obtained from all the subjects.ALDH2 genotypes were detected by PCR RFLP method.The frequencies of ALDH2 variant genotypes(G/A+A/A)in cases with esophageal cancer and controls were 43.88% and 47.25% respectively.No difference was found between two groups.There was a significant difference between alcoholics (<3 times/week)with G/G genotype and alcoholics(≥3 times/week)with G/A+A/A genotypes in male.[Conclusion]Frequent alcoholic consume may influence the relationship between polymorphisms of ALDH2 and susceptibility of esophageal cancer.