泰兴市HBsAg与其它危险因素致肝癌交互作用的研究

The Study on the Interactions between HBsAg and Various Risk Factors in Primary Hepatocellular Carcinoma in Taixing Area

[目的]探索泰兴市HBsAg与其它危险因素致肝癌的交互作用。[方法]选择88例原发性肝癌新发病例按性别、年龄和居住地进行1∶1配对的病例对照研究 ,对全部研究对象检测了HBsAg和抗 HCV。[结果]病例组HBsAg和抗 HCV阳性率(72.73%和7.95%)显著高于对照(22.73%和1.13%) ,HBsAg阳性同时又暴露于慢性肝炎、性格忧郁、受过重大精神刺激及每次饮酒量多因素致肝癌发生的OR值分别为40.86、22.73、47.37和29.06,其两因素交互作用指数分别为0.7657、0.6364、0.8251和0.6469。

To assess the interactions between HBsAg and various risk factors in primary hepatocellular carcinoma(PHC) in Taixing Area.A case control study including 88 cases of newly diagnosed PHC and 88 controls matched on sex,age and resident area was carried out,blood samples from all individuals were collected and tested for serum HBsAg and anti HCV.The positive rates of serum HBsAg and anti HCV between new cases and controls showed significant differences,much higher in new cases (72.73% and 7.95%)than those in controls (22.73% and 1.13%).Subjects with both HBsAg positive and any of the following factors:chronic hepatitis,melancholy temperament,great spirit irritation and higher comsuption of alchhol were at a significantly higher risk of developing PHC(OR=40.86,22.73,47.37 and 29.06).The interaction index were 0.7657,0.6364,0.8251 and 0.6469,respectively.[Conclusion]These findings indicate there was a significantly combined effect between HBsAg and above risk factors in developing PHC in Taixing Area.