IL-6、CRP、CA_(125)在卵巢肿瘤定性诊断中的价值及临床意义

Differential diagnostic value and clinical significance of IL-6,CRP and CA_(125) in ovarian tumor.

目的 :探讨测定血清IL 6、CRP、CA12 5水平在卵巢肿瘤定性诊断中的价值及临床意义。方法 :取卵巢肿瘤 61例患者的血浆及 17例合并腹水患者的腹水 ,用ELISA法及胶乳凝集法测定IL 6、CA12 5、CRP。结果 :IL 6诊断卵巢癌敏感性为 80 .9% ,特异性为77.3%。CA12 5诊断卵巢癌敏感性为 85 .7% ,特异性为 80 .9%。这二项指标联合检测 ,敏感性为 92 .5 % ,特异性 73.9%。CRP诊断卵巢癌敏感性达 76.2 % ,特异性 60 .0 %。临床分期晚、组织分化低者血清及腹水IL 6、CA12 5水平明显升高。结论 :IL 6、CA12 5是卵巢肿瘤定性诊断的良好指标 ,联合检测可提高定性诊断的敏感性及特异性。腹水或血中IL 6、CA12 5水平可为卵巢癌早期诊断、分期及判断预后提供有效的参考指标。

Objective:To determine the level of serum IL-6,CRP,CA 125 and explore the differential diagnostic value and clinical significance of the tumor markers in patients with ovarian tumors.Methods:Using ELISA or latex agglutination assay,serum and ascitic fluid IL-6,CA 125 and CRP in 61 cases of ovarian tumors were measured.Results:Sensitivity and specificity of IL-6,CA 125 and CRP were 80.9% and 77.3%,85.7% and 80.9%,76.2% and 60.0% respectively.Sensitivity and specificity of the combination of IL-6 and CA 125 were 92.5%,73.9% respectively.The levels of IL-6,CA 125 of serum and ascitic fluid in patients with advanced stage or lower histological differentiation were significantly higher than those in patients with early stage or higher histological differentiation.Conclusions:IL-6,CA 125 are effective directors in the differential diagnosis of ovarian tumor,and combination assay of those parameters may be of value in distinguishing ovarian benign tumor from malignant tumor.The levels of IL-6,CA 125 of serum and ascitic fluid may provide useful director in early diagnosis,dicision of clinical stages and prognosis of ovarian tumor.