生物健对小鼠免疫功能的影响

Effects of Shengwujian Oral Liquid on Immune Function in Mice

目的 研究生物健对小鼠体液免疫、细胞免疫、红细胞免疫和单核 -巨噬细胞系统的作用。方法 用正常小鼠、环磷酰胺 (CY)致免疫抑制和 2 ,4二硝基氟苯 (DNFB)诱导迟发型超敏反应 (DTH)小鼠模型 ,研究生物健对小鼠IgG和补体C3 含量、白细胞总数 (WBC)、红细胞免疫粘附、DTH作用和碳粒廓清能力等实验指标的影响。结果 生物健能提高正常和免疫抑制小鼠IgG和补体C3 含量 (P <0 .0 5 ) ;提高低白模型小鼠WBC数量 (P <0 .0 1) ;增强红细胞免疫粘附能力 (P <0 .0 1) ;增强碳粒廓清能力 (P <0 .0 1)和DNFB诱导DTH (P <0 .0 1)。结论 生物健能增强小鼠 (尤其是免疫抑制状态下 )体液、细胞免疫功能和非特异性的红细胞免疫粘附能力、碳粒廓清能力 。

? Objective To investigate effects of Shengwujian oral liquid on humoral immunity,cellular immunity,red blood cell (RBC) immunity and macrophage-phagocyte system (MPS).Methods To observe the effects of Shengwujian oral liquid on serum IgG and complement C 3 content,white blood cell (WBC) count,RBC immune adhering function,2,4-dinitrofluorobenzene(DNFB)induced-delayed type hypersensitivity (DTH) and phagocytic ability of macrophage in either normal mice or cyclophosphamide (CY)-induced-immunosuppressed mice.Results Serum IgG and complement C 3contents were increased in normal and/or CY-induced-immunosuppredded mice (P<0.05);CY-induced-leucopenia was improved (P<0.01);RBC immune adhering function was enhanced (P<0.01);phagocytosis of macrophage was elevated (P<0.01);DNFB induced-DTH was potentiated (P<0.01).Conclusion Shengwujian oral liquid possesses a similar ability of a biological response modifier as levamisole.