依扑拉芬对去卵巢大鼠子宫内膜的影响

THE EFFECTS OF IPRIFLAVONE ON THE ENDOMETRIUM OF OVARIECTOMIZED RATS

目的 :观察依扑拉芬治疗去卵巢大鼠骨质疏松时对子宫内膜的影响。方法 :2 4只 4月龄雌性SD大鼠随机分为 3组 :假手术组、模型组、依扑拉芬组 ,每组 8只 ,术后 15天开始给药 ,用药 6 0天后 ,处死大鼠取子宫 ,对其子宫内膜进行形态学检查。结果 :模型组与假手术组、依扑拉芬组比较 :大鼠子宫内膜上皮较薄 ,腺体数目显著减少 ,腺体缩小 ;依扑拉芬组与假手术组比较 :形态表现相似 ,但腺体较小 ,腺体数目两组差异无显著性。结论 :在治疗去卵巢大鼠骨质疏松的过程中 ,依扑拉芬有维持子宫内膜生长作用 。

Objective:To observe the effect of ipriflavone on the endometrium of osteoporosis rats by ovariectomized.Methods:24 rats of 4-month old SD female were randomly divided into 3 groups, namely sham operation group, bilateral ovariectomy group (sample group), and ovariectomy plus supplementary ipriflavone group (Ipriflavone group).Results:After treated by ipriflavone 60 days, the results showed that there were fewer glands of endometrium in sample group than those in the sham operation group. There were smaller glands in ipriflavone group than those in the sham operation group, but on the number of gland there were no significantly difference between the two groups.Conclusions:Ipriflavone may maintain the growth of endometrium, but its effect is weaker than estrogen's.