心肌梗塞面积无损计测数学模型

NONINVASION MEASURING MATHEMATICAL MODEL OF MYOCARDIAL INFACT SIZE

本文根据生物电学电极化理论,引入心肌梗塞向量,定量地描述心肌梗塞面电偶层源的形成,运用电动力学源场关系,首次建立计测心肌梗塞面积的理论数学模型.此数学模型计测方法简易,所需导联电极数少,而测得信息较多,属于无损伤非侵入性,便于临床推广应用.经动物实验验证,本数学模型计测所得心肌梗塞面积与组织化学染色切片实测面积,两者极显著正相关,心前壁与前间壁心肌损伤r=0.96(n=12,P<0.01);侧壁、后壁、下壁心肌坏死r=0.93(n=10,P<0.01).在临床上,与ECT相对照,r=0.91(r=14,P<0.01),极显著相关.

Dynamic and quantitative of measurement myocardial infarction 'area' is beneficial to monitoring forecast, treatment and prognosis of the patients. There was a variety of methods measuring myocardial infarction 'area' , but few of them suited to clinical medicine. The present paper analyzed the formation of eletric dipole layers on the infarction (ischemia, injury, necrosis) surfaces at the cardiac cell and membranes according to electric polarization theory from electrocardiodynamics and electrobiology, introduced the myocardial infarct vectors including ischemia, injury, and necrosis vectors and established the mathematical model of measuring myocardial infarction 'area' for the first time. The features of the model are (1) the model was established on the tasis of thinking from origin to field. The electro-biology theory analysis on the origin was deeper, and the surveying method was more simple on the field as well as non-invasive; (2) by means of the model not only the sizes of the infarction area could be measured, but also the positions (frontal, frontoseptal, lateral, back and lower wall) and characteristics (subexoc-ardial, subendocardial and perforated) of the infarction area could be determined; (3) the animal and clinical experiment showed that there were significant positive correlation between the two results calculated measured r>0.90 (P>0.01) .