霉酚酸酯在治疗系统性红斑狼疮肾脏损害中的应用
摘要
应用免疫抑制剂治疗系统性红斑狼疮取得了显著成就,但治疗效果及存在的副作用并不能令人真正满意,新型免疫抑制剂层出不穷。现就最近上市的免疫抑制药物霉酚酸酯治疗红斑狼疮肾脏损害的作用机制、动物实验、临床应用和副作用情况作一简要综述。
出处
《国外医学(皮肤性病学分册)》
2001年第6期335-338,共4页
Foreign Medical Sciences(Section of Dermatology and Venereology)
参考文献17
-
1Ishikawa H.Mizoribine and mycophenolate mofetil.Curr Med Chem,1999.6(7):575-597.
-
2Eugui EM,Almquist S J,Muller CD,et al.Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro:role of deoxyguanosine nucleotide depletion.Scand J Immunol,1991,33(2):161-173.
-
3Zeevi A.Woan M.Yao GZ.et al.Comparative in vitro studies on thr immunosuppressive activities of mycophenolic acid,bredinin,FK-506,cy closporine,and rapamycin.Transplant Proc,1991,23(6):2928-2930.
-
4Grailer A,Nichols J,Hullett D,et al.Inhibition of human B cell re-spouses in vitro by RS-61443,cyclosporine A and DAB486IL-2.Trans-plant Proc,1991,23(1 Pt 1):314-315.
-
5Lemster B,Woo J,Strednak J,et al.Cytokine gene expression in murine1ymphocytes activated in the presence of FK-506,bredinin,mycophenolicacid,or brequinar sodium.Transplant Proc,1992,24(6):2845-2846.
-
6Jonsson CA,Erlandsson M.Svensson L,et al.Mycophenolate mofetilameliorates perivascular T lymphocyte inflammation and reduces the double-negative T cell population in SLE-prone MRLlpr/lpr mice.Cell Im- munol.1999.197(2):136-144.
-
7Jonsson CA,Svensson L,Carlsten H.Beneficial effect of the inosinemonophosphate dehydrogenase inhibitor mycophenolate imofetil on survival and se verity of glomerulonephritis in systemic lupus erythematosus (SLE)-prone MRLlpr/lpr mice.Clin Exp Immunol,1999,116(3):534-541.
-
8Van Bmggen MC,Walgreen B,Rijke TP,et al.Attenuation of murine lupus nephritis by mycophenolate mofetil.J Am Soc Nephrol,1998,9(8):1407-1415.
-
9McMurray RW,Elboume KB,Lagoo A,et al.Mycophenolate mofetil suppresses autoimmunity and mortality in the female NZB x NZW Flmouse model of systemic lupus erythematosus.J Rheumatol,1998.25(12):2364-2370.
-
10Glicklich D,Acharya A.Mycophenolate mofetil therapy for lupus nephritis refractory to intravenous cyclophosphamide.Am J Kidney Dis,1998,32 (2):318-322.
-
1王健,刘晓青,潘欢弘,程慧健.手足口病的流行及其预防控制概况[J].海峡预防医学杂志,2009,15(6):22-24. 被引量:41
-
2黄远航,朱起之.霉酚酸酯治疗类风湿性关节炎[J].中华肾脏病杂志,2001,17(4):278-278. 被引量:1
-
3周方,陈贵诚,高晓春,吴杰.霉酚酸酯治疗难治性肾病综合征9例疗效观察[J].广西医学,2000,22(1):206-206. 被引量:3
-
4刘仰东,杨德安,李香铁,徐友和,刘少鸽,郝俊文,张爱民.霉酚酸酯治疗肾移植术后慢性排斥反应10例[J].医药导报,2003,22(4):260-261.
-
5巩建华.霉酚酸酯治疗难治性肾病综合征疗效观察[J].临床肾脏病杂志,2004,4(3):102-102.
-
6马聪,陈民.霉酚酸酯治疗肾病综合征10例观察[J].中国冶金工业医学杂志,2004,21(6):501-502.
-
7王霄一,沈琴儿,施占琴,张东伟.霉酚酸酯治疗难治性肾病综合征的临床探讨[J].临床医学,2004,24(12):12-13.
-
8刘晓青,冯子健,张静.伤寒副伤寒防控对策研究[J].疾病监测,2008,23(1):56-58. 被引量:20
-
9潘长旺,谭峰.我国广州管圆线虫病流行病学研究进展[J].国际医学寄生虫病杂志,2009(5):336-342. 被引量:3
-
10世界卫生组织发布《2012年全球结核病报告》[J].中国卫生政策研究,2012,5(11):59-59. 被引量:3