695例茶碱血药浓度监测分析

Analysis of serum concentration of the ophylline in 695 patients

目的 :了解影响茶碱血药浓度的因素以指导临床用药。方法 :本文对接受茶碱维持量疗法的 6 95例患者的茶碱血药浓度监测结果进行了回顾性分析。结果 :35 .1%的病例茶碱血药浓度在有效血药浓度范围内 (10～ 2 0 μg/ml) ,35 .8%的病例茶碱血药浓度低于 10 μg/ml,2 9.1%的病例茶碱血药浓度高于 2 0 μg/ml;环丙沙星、氟罗沙星、沙丁胺醇提高茶碱血药浓度 ;特布他林、利福平、速尿降低茶碱血药浓度 ;合并肝功能异常、肺心病患者茶碱血药浓度偏高 ;嗜烟患者茶碱血药浓度偏低。结论 :茶碱血药浓度个体差异大 ,药物因素、疾病因素、嗜好等影响茶碱血药浓度 。

OBJECTIVE: To realize the factors of affecting the serum concentration of theophylline. METHOD: The data of 695 patients who whose the serum concentration of theophylline were determined analyzed. RESULTS: 35.1% of the cases had the effective serum concentration of theophylline (10～20μg/ml),35.8% cases had relatively lower concentration, and 29.1% cases had relatively higher. Ciprofloxacin, fleroracin and salbutamol increase the serum concentration of theophylline. Terbutaline, rifampicin, and lasix decrease the serum concentration of theophylline. The patients with abnormal liver function or pneumo cardiopathy have the prone to make the serum concentration of theophylline on the high side, whereas the patients being addicted to smoking have the prone to make the serum concentration of theophylline on the low side. CONCLUSION: There is great individual difference in the serum concentration of theophylline, factors of combining drugs and other diseases and hobbies will affect the serum concentration of theophylline. The study indicated that it is important to improve the safety and effectiveness of theophylline to monitor the serum concentration.