平痛新素丸的处方设计及制备

Formulation design and preparation of nefopam blank pellets

目的 :为制备平痛新包衣微丸提供良好的底物。方法 :以流动性指数为指标采用均匀设计优化平痛新素丸。结果 :确定了制备平痛新素丸的最佳处方工艺。结论 :淀粉量是影响产率的主要因素 ;转速是影响堆密度、脆碎度的主要因素 ;粘合剂用量是影响休止角和流动性的主要因素 ;

OBJECTIVE: To provide good basis for preparing Nefopam coated pellets. METHODS: Using the liquidate index as the evaluating parameter,uniform design was adopted to optimize Nefopam blank pellets. RESULTS: The optimal preparation process of Nefopam coated pellets was determined. CONCLUSION: The amount of starch was the main factor affecting the produce rate; the rev was the main affecting factor of the bulk density and the friability; the amount of adhesives was the main affecting factor of the angle of repose; the rolling time was the main affecting factor of the cascade index.