帕罗西汀与阿米替林治疗抑郁症对照研究的Meta分析

A Controlled Study on Paroxetine and Amitriptyline in Treatment of Depression: A Meta-analysis

目的 :进一步认识帕罗西汀与阿米替林治疗抑郁症的疗效和不良反应差异。方法 :收集国内医药杂志上公开发表的 6篇帕罗西汀与阿米替林对照治疗抑郁症研究的文章 ,作Meta分析。结果 :帕罗西汀自身对照比较的治疗效应极大 ,与阿米替林组间比较没有显著性 ,差异效应偏小 ;帕罗西汀组的心动过速、锥外反应、便秘、口干和视力模糊 ,显著少于阿米替林组 ,差异有显著性 ,差异强度偏大。结论 :帕罗西汀与阿米替林 6周的疗效无差异 。

Objective: To compare further the differences of therapeutic effect and adverse reactions between paroxetine(Par) and amitriptyline(Ami). Methods: Meta-analysis was made to comparatively study on Par and Ami by six literature published from internal medical journals. Results: The significant difference between pre- and post-treatment in group Par was found, a excellent therapeutic effect have been obtained. No difference was found between group Par and group Ami after treatment, and difference efficacy was not significant. The incidence of techycardia, extra-pyramidal syndrome, constipation, dry mouth, blurred vision in group Ami was significantly different from group Par and lower than group Par, the intensity of difference was partially higher. Conclusions: There is difference between Par and Ami in the therapy effect of six weeks, but it is a obvious different in adverse reactions.