“脑还丹”对老龄去势大鼠血清IGF-Ⅰ和血脂水平的影响

The Influence of Naohuadan on the Level of Serum IGF-Ⅰ and Lipoprotein Metabolism in the Ovariectomized Rat

为了探讨“脑还丹”防治神经原退行性变的机制 ,本文从血清IGF Ⅰ和血脂的变化观察了该方对老龄去势大鼠 (肾虚模型 )的病理生理影响。结果表明 ,“脑还丹”能显著降低卵巢结扎大鼠LDL c和TC的血清浓度 ,高剂量可显著提高HDL、TG和血清IGF Ⅰ的水平。说明“脑还丹”保护神经原的作用是通过调节血脂及IGF Ⅰ水平等途径实现的。

The research focus on the influence of Naohuandan on the level of serum insulin like growth factor Ⅰ (IGF Ⅰ)and lipoprotein metabolism in order to determine the mechanism of the recipe on neurodegeneration in the ovariectomized rats. The results show that the total cholesterol and low density lipoprotein cholesterol of Naohuandan groups were significantly lower than that of control group; triglycerides, and high density lipoprotein cholesterol and serum IGF I of the recipe were significantly higher than that of control group. IGF Ⅰ between the control group and conjugated estrogen group had significant difference. The results indicate that Naohuandan could effectively regulate the metabolism of lipoprotein and serum IGF Ⅰ to protect the neurons.