炙甘草汤及有效成分对组胺诱发离体豚鼠乳头肌触发活动及动作电位影响

Influence of Zhigancao Decoction and Active Components on Triggered Activity and Action Potential by Histamine in Guinea Pig Papillary Muscle

炙甘草汤是古典名方 ,现临床用于治疗心律失常。本文用标准微电极技术观察离体豚鼠乳头肌动作电位的变化 ,研究炙甘草汤及有效成分抗组胺触发活动作用。炙甘草汤 (4 0mg ml)及有效成分 (1 36mg ml)能防治组胺 (2 0 0 μmol L)对APD50 和APD90 的缩短 ,并能防治组胺诱发的EAD ,DAD和TA的发生。

Zhigancao Decoction is a famous traditional medicinal formula. At present the decoction can treat the arrhy thmia in clincical practice. By using standard microelectrode techniques to guinea pig papillary muscle, Zhigancao Decoction (40mg·ml -1 ) and active component (1 36 mg·ml -1 )could prolonge the shortening of APD 50 and APD 90 and reduced the incidence of triggered activities (EAD,DAD and TA) by histamine (200μmol·L -1 ).