急性脑血管病患者血清和脑脊液肿瘤坏死因子、白介素及免疫球蛋白水平与免疫功能关系的临床研究

The clinical study on the relationship of immunity and levels of tumor necrosis factor-α,interleukin-2 and immunoglobulin in serum and cerebrospinal fluid in patients with acute cerebrovascular disease

目的 :探讨肿瘤坏死因子 α(TNFα)、白介素 2 (IL 2 )和免疫球蛋白 (Ig)与急性脑血管病(ACVD)的关系。方法 :采用放射免疫分析法测定了 80例 ACVD患者血清及 6 0例 ACVD患者脑脊液 (CSF)中 TNFα、IL 2和 Ig含量 ,并与 30例正常对照组比较。结果 :ACVD患者血清和 CSF中 TNFα、IL 2和 Ig水平明显高于对照组 (P均 <0 .0 1) ,以 CSF中 TNFα和 Ig改变最明显 (P均 <0 .0 0 1) ,且与病情程度明显相关 (P<0 .0 1)。治疗后 TNFα、IL 2和 Ig水平随病情好转、血脑脊液屏障的修复逐渐趋于正常。结论 :ACVD发病过程中存在 TNFα、IL 2介导的免疫反应 。

Objective:To investigate the relationship of tumor necrosis factorα(TNFα),interleukin2(IL 2) and immunoglobulin(Ig) with acute cerebrovascular disease (ACVD).Methods:The concentrations of TNFα,IL2 and Ig were measured by radioimmunoassay in 80 patients in serum and 60 patients with ACVD in cerebrospinal fluid(CSF),and the results were compared with those in 30 healthy controls.Results:The levels of TNFα,IL2 and Ig in serum and CSF in these patients were significantly higher than those of the controls(all P <0 01),especially TNFα and IL2 in the CSF were more higher (all P <0 001).The severity of the disease were significantly relatived with the changes of TNFα,IL2 and Ig in serum and CSF in patients with ACVD ( P <0 01).The levels of TNFα,IL2 and Ig were recovered after treatments.Conclusions:An immunological response mediated by TNFα and IL2 is present in the pathogenesis of ACVD.Bloodbrain barrier function is injured in different extent in patients with ACVD.