慢性肾功能衰竭血清芳香酯酶活性改变的研究

CHANGE OF SERUM ARYLESTERASE ACTIVITY IN CHRONIC RENAL FAILURE

目的研究慢性肾功能衰竭 (CRF)患者血清芳香脂酶 (ArE)活性改变的临床意义。方法 :通过测定CRF早期、晚期与终末期患者血清ArE活性、胆固醇、高密度脂蛋白胆固醇 (HDLc)、氧修饰低密度脂蛋白 (ox -LDL)与脂蛋白 (a) [Lp(a) ]及内生肌酐清除率 (Ccr)等的水平 ,进行分析。结果 :CRF患者血清ArE活性与HDLc水平低于对照组 ,血清ox -LDL、Tc与LP(a)水平高于对照组。三期肾功能衰竭患者血清ArE活性与HDLc水平降低程度自小至大依次为早期、中期与晚期 ,血清ox -LDL、Tc与LP(a)升高程度在三组间有显著性差别 ,其中以终末期最高。血清ArE活性与HDLc、白蛋白、Ccr呈正相关 ,与血清肌酐呈负相关 ,和Lp(a)无相关性。结论 :测定CRF患者血清ArE活性不仅了解其血脂与脂蛋白的代谢异常 ,还可为了解肾功能损害程度提供参考依据。

Objective:To understand the variance of serum arylesterase (ArE) activity in patients with chronic renal failure in various degree of pathological change,namely early stage,intermediate stage,end stage,and its clinical significance.Method:The ArE activity,total cholesterol (Tc),high density lipoprotein_cholesterol (HDLc),oxidized low density pipoprotien (ox_LDL),lipoprotien(a),albumin (AlB) and creatinine clearance (Ccr) were determined in serum of patients with three stages of chronic renal failure (CRF) patients.Results:ArE activity (0.210±0.036u/ml) in serum of CRF,was significantly lower than that (0.258±0.018u/ml) of control group.Ox_LDL and Lp(a) was significantly increased.Serum ArE activity had a positive correlation with HDLc,AlB and Ccr.There was a negative correlation between activity of ArE and ox_LDL,serum creatinin.Conclusions:There was a relationship between the change of ArE activity and abnormally metabolism,Ccr in patients with CRF.Serum ArE was one of the good indexes to reflect the disorder of lipid metabolism of CRF and to understand the serious degree of pathological change of CRF.