摘要
目的 :探讨细胞凋亡相关蛋白的Fas、FasL在胃癌发生、发展中的作用。方法 :对 74例手术切除胃癌标本 ,应用免疫组化S P法检测Fas、FasL蛋白在癌组织和相应癌旁组织中的表达。结果 :在高中分化型胃癌Fas和FasL的阳性表达率一致性显著高于低分化型胃癌 (P <0 0 5 )。而在早期和进展期胃癌间 ,有淋巴结转移和无淋巴结转移胃癌间Fas和FasL的阳性表达率无显著性差异 (P >0 0 5 )。胃癌组织Fas阳性表达率显著低于癌旁组织 (P <0 0 5 )。FasL在两者间无显著性差异 (P >0 0 5 )。结论 :Fas和FasL的异常表达可能是胃粘膜癌变过程中细胞凋亡抑制的重要机制之一 ,并与胃癌的分化和免疫逃逸有关。
Purpose: To study the relationship between the expression of Fas and Fas L protein and the pathogenesis and devolopment of gastric cancer. Methods: The expression of Fas and Fas L protein were exammed by S P immunohistochemistry. Results: The expression of Fas and Fas L was correlated with the degree of differentiation, but not correlated with the depth of invasion and metastasis of lymph node. The positive rate of Fas in gastric cancer was significantly lower than the adjacent noncancerous tissue. But the expression of Fas L wasn't significantly different in gastric cancer and the adjacent noncancerous tissue. Conclusion: The abnormal expression of Fas and Fas L maybe involve in the pathogenesis and the immune escape of gastric cancer, and also in the degree of differentiation.
出处
《临床消化病杂志》
2002年第1期9-11,共3页
Chinese Journal of Clinical Gastroenterology
