糖尿病合并急性心肌梗死和缺血性脑梗塞患者血浆纤溶成分与血脂水平的变化

Variation of Plasma t-PA,PAI and Lipid Levels in Patients of Diabetes Complicated with Acute Myocardial Infarction and Ischemic Cerebral Infarction

目的探讨糖尿病患者并发急性心肌梗死和缺血性脑梗塞时血糖、血脂、组织型纤溶酶原激活剂 (t- PA)及其抑制物 (PAI)的水平变化及临床意义。方法该院内科收治的 98例糖尿病合并急性心肌梗死和缺血性脑梗塞患者为观察组 ,与 40例健康对照组进行比较。观察指标为血 t- PA、PAI、血脂、血糖。结果观察组的血糖 (FBG)、胆固醇 (TC)、甘油三酯 (TG)及 PAI含量明显高于对照组 ,而高密度脂蛋白 (HDL- C)、t- PA含量明显低于对照组 (P均 <0 .0 1)。结论糖尿病合并急性心肌梗死和缺血性脑梗塞患者存在血糖、血脂及血纤溶功能异常。

Objective To investigate the levels of plasma tissue type plasminogen activator(t PA),plasminogen activator inhibitor (PAI) and lipids in patients of diabetes complicated with acute myocardial infarction and ischemic cerebral infarction and clinical significance of these indexes.Methods In our ward there were 98 patients of diabetes complicated with acute myocardial infarction and ischemic cerebral infarction in the observed group and there were 40 health in the control group.Observed indices were plasma t PA,PAI,lipids and blood sugar.Results Contents of fasting blood glucose (FBG),total cholesterol (TG),triglyceride (TG) and plasminogen activator inhibitor (PAI) in observed group were significantly higher than that in control group ( P <0 01).Contents of HDL C and t PA in observed brorp were significantly lower than that in control group ( P <0 01).Conclusion There were abnormal lipids and fibrinolytic activities in patients of diabetes complicated with acute myocardial infarction and ischemic cerebral infarction.Variation of fibrinolytic components is possible closely related to thrombosis.