格拉司琼与恩丹西酮预防化疗后恶心、呕吐的成本-效果分析

Comprison of the Cost-effectiveness Between Granisetron and Ondansetron in Preventing Nausea and Vomiting Caused by Cancer Chemotherapy

目的 :比较格拉司琼与恩丹西酮预防化疗后恶心呕吐的疗效、不良反应及成本 -效果。方法 :以相关疗效指标及药物经济学成本 -效果分析法进行评价 ,观察药物不良反应。结果 :格拉司琼预防化疗后恶心、呕吐的有效率分别为83 6 %和86 8 %,每化疗周期人均费用为210 48元 ,成本 -效果比分别为251 77和242 37 ;恩丹西酮的有效率分别为72 9 %和83 7 %,每化疗周期人均费用为381 35元 ,成本 -效果比分别为523 11和456 62。两组患者均未发现不良反应。结论 :格拉司琼能有效地预防化疗后的恶心、呕吐 ,成本 -效果比优于恩丹西酮。

OBJECTIVE:To compare the therapeutic effect,adversere reactions and cost-effectiveness between granisetron and ondansetron in preventing nausea and vomiting caused by cancer chemotherapy.METHODS:Using pharmacoeconomic co_st-effectiveness analysis,the relevant therapeutic indices were evaluated.RESULTS:The effective rates of granisetron in preventing nausea and vomiting were 83.6% and 86.8% with an average cost of 210.48 yuans in a therapeutic couse,the cost-ef_fective ratio being 251.77 and 242.37,and those of ondansetron were 72.9% and 83.7% with an average cost of 381.35 yuans,the cost-effective ratio being 523.11 and 456.62.CONCLUSION:Granisetron can effectively prevent nausea and vomiting caused by cancer chemotherapy,and its cost-effective ratio is superior to that of ondansetron.