济南市女性乳腺癌危险因素的病例对照研究

CASE-CONTROL STUDY ON THE RISK FACTORS OF BREAST CANCER AMONG WOMEN IN JINAN

目的 :探讨影响济南市女性乳腺癌发病的危险因素。方法 :对济南市 186例女性乳腺癌患者进行了 1:1配对病例对照研究。结果 :在单因素分析中有显著性意义的危险因素为乳腺良性病史、初产年龄≥ 30岁、月经不规律及被动吸烟 ,保护因素为哺乳史、绿叶蔬菜摄入量及大豆类食品 ;在条件Logistic回归分析中 ,有显著性意义的危险因素是良性乳腺疾病史和初产年龄晚 ,保护因素是哺乳和大豆类食品。结论 :济南市女性乳腺癌的重要危险因素为良性乳腺疾病史及初产年龄偏大。

Objective:To explore the risk factors of breast cancer among women in Jinan.Methods:A 1:1 matched case control study was performed in 186 cases with breast cancer who lived in Jinan area.Results:In the univariate analysis, history of benign breast diseases, primiparity ≥30 years, irregular menstruation , and passive smoking are the statistically significant risk factors of breast cancer, whereas breast feeding , intakes of vegetable and soybean food consumption are protective factors. Conditional logistic multivariate analysis revealed that history of benign breast diseases and later primiparity age are risk factors while soybean food products and breast feeding are protective factors.Conclusion:The risk factors of breast cancer amog women in Jinan are history of benign breast diseases and later primiparity age.