氟接触工人神经行为功能的研究

Study on Neurobehavioral Function of Workers Occupationally Exposed to Fluoride

目的 探讨氟接触工人神经行为功能的改变及其接触水平 -效应关系。方法 采用WHO推荐的神经行为功能测试组合 (NCTB)对某铝厂 6 5名电解工人和 5 2名对照工人进行测试分析 ,同时测定其血清氟、尿氟浓度。结果 血清氟、尿氟浓度接触组明显高于对照组。除视觉保留外 ,氟接触工人的各项测试标准分均低于对照组。除视觉保留、数字译码外 ,血清氟浓度与NCTB各项测试间均存在明显负相关。结论 职业性氟接触可影响工人正常的神经行为功能 ,血清氟浓度与神经行为功能间可能存在一定接触水平-效应关系。

Objective Neurobehavioral function of fluoride exposed workers and the exposure effect relationship were studied.Methods 65 workers from aluminum plant were taken as the exposed group and 52 healthy workers as the control group.Neurobehavioral Core Test Battery(NCTB)recommended by WHO was used for observation.Meanwhile,the concentrations of serum and urine fluoride were detected.Results Compared with the control group,concentrations of serum and urine fluoride of the exposed group increased.There was significant difference of NCTB between the exposed and the control group except Benton visual retention.The concentration of serum fluoride correlated inversely with most items of NCTB except digit symbol and Benton visual retention.Conclusions Occupational fluoride exposure might interfere with normal neurobehavioral function.The exposure effect relationship between the concentrations of serum and urine fluoride and NCTB scores might exist,so NCTB could be one of the effective and sensitive indexes for aluminum workers health surveillance.