安氏Ⅱ类1分类错的遗传特征初探

A genetic feature study in ClassⅡ,division 1 malocclusion

目的 通过分析安氏Ⅱ类 1分类错牙合的特征性指标的亲子间相似性 ,初步探讨安氏Ⅱ类 1分类错牙合的遗传特征 ,并分析其对临床矫治的指导意义。方法 通过t检验 ,比较 6 1例安氏Ⅱ类 1分类错牙合患者与 10 0例正常牙合人的颅面结构 ,找出特征性指标 ,分析特征性指标与非特征性指标亲子间相关关系的差异。结果 ① 10 4个测量项目中有 43项的正常牙合与错牙合间有显著性差异 ,且在颅面部不同部位中 ,这些指标的比例不同 ,有显著性差异的指标占 5 0 %以上的部位主要为下颌骨 (5 3% ) ,牙槽部 (5 7% )及上下颌间关系 (10 0 % ) ;②通过逐步判别分析 ,筛选出 12个判别函数 ,回代后错判率为 8.5 4% ;③安氏Ⅱ类 1分类错牙合的特征性指标其亲子间相似性较非特征性指标强。结论 ①本组安氏Ⅱ类 1分类错牙合主要由下颌骨、牙槽部及上下颌间关系的畸形造成 ;②安氏Ⅱ类 1分类错牙合可能并不是简单地由几种不协调的颅面结构随机组装而成 ,而很可能是在某种程度上作为一个整体遗传的 ;③上颌牙齿 (包括切牙和磨牙 )是矫治安氏Ⅱ类

Objective To study the genetic feature of ClassⅡ division 1 malocclusion and analyse the clinical implication.Methods Compare the craniofacial structure between 61 ClassⅡ division 1 malocclusion patients and 100 normal occlusion samples to find the charactersistic measurements of Class Ⅱ division 1 malocclusion and analyse the similarity between parent-offspring in the characteristic measurements.Results ①There were 43 characteristic measurements in 104 relationships;②By stepwise discrimination analysis,12 discrimination functions selected;③Characteristic measurements had stronger similarity between parents and offsprings than others.Conclusion ①Maybe there are some special genetic features in ClassⅡ division 1 malocclusion;②For clinical implication,the upper teeth are one of the key to treat the ClassⅡ division 1 malocclusion.