天花粉四种给药途径及合并地塞米松引产临床分析

Clinical Trial of Trichosanthin with or without Dexamethasone in Induction of Abortion by Four Different Routes of Administration

本文研究天花粉蛋白四种不同给药途径及合并使用地塞米松对引产疗效及副反应的影响。结果表明,不同给药途径引产有效率基本相同,但副反应明显不同。羊膜腔用药反应最轻;宫腔用药较轻;宫颈法较宫腔法重;肌肉用药反应最重,而且有注射局部反应。应用地塞米松对天花粉引起的全身副反应有明显的轻缓作用。

This paper shows that the efficacy of Trichosanthin(TCS)in inducing abortion wasconsistent but the side effects varied with different routes.The injection of TCS into the amni-otic sac during 16-24 gestation weeks gave the slightest side effects.The side effects in intra-uterine injection were more sevre than in intra-amniotic injection and those in intra-cer-vical injection were more severe than in intrauterine injection.The intra-muscular injectionhad the most severe side effects and local reaction at the injected site.Dexamethasone didnot influence the effectiveness of abortion but could obviously reduce the side effects pro-duced by any route of administration.