蛋白质沉淀结晶研究进展

Research Progress in the Precipitation and Crystallization of Proteins

论述了国内外生物大分子 (蛋白质、酶等 )沉淀结晶的研究现状和进展 ,着重从结晶热力学、粒子聚集、结晶的成核与晶体生长 ,以及场的作用等方面阐述了蛋白质沉淀结晶过程的特定现象与可能的结晶机理 ,对蛋白质的沉淀结晶过程作了全面的描述 ,并提出未来研究方向 ,为蛋白质结构分析、新药设计。

Focusing on the research progress of the precipitation and crystallization of proteins,the special phenomenon and crystallization mechanism of such biological macromolecules as proteins,enzymes,etc.have been expatiated from the studies of crystallization thermodynamics,aggregation,nucleation,crystal growth,and external fields,which provides some basis for structural analysis,pharmaceutical design,biochemical research and industrial production.