选择性甲基化合成赛克津中间试验研究

Research on the Scale-up Test of Synthesis for Metribuzin by the Method of Selecting Methylation

以作者研究成功的 4 氨基 6 特丁基 3 甲硫基 1,2 ,4 三嗪 5 (4H) 酮 (赛克津 )合成新方法小试技术条件为依据 ,进行了赛克津中间试验放大过程工艺研究。中间试验结果 :以中间体 4 氨基 6 特丁基 3 巯基 1,2 ,4 三嗪 5 (4H) 酮 (简称三嗪 )为原料计 ,收率 >90 % ,有效成分含量 >90 %

A new technology of synthesis Metribuzin was reported.Using 4 amino 6 tert butyl 3 mercapto 1,2,4 triazin 5(4H) one as starting material,on the basis of the experimental study,the scale up test was performed.The results indicate that the yield of the reaction is higher than 90%,the purity of the product is higher than 90%.