铝接触对工人脂质过氧化水平的影响

Studies on lipid peroxidation level in serum of workers exposed to aluminum

目的 研究铝接触对工人脂质过氧化水平的影响。方法 选取某铝厂工人 6 5人 ,观察血清铝、尿铝浓度 ,血清中谷胱甘肽过氧化物酶 (GSH Px)活力、丙二醛 (MDA)含量及红细胞中超氧化物歧化酶(SOD)活力的变化情况。结果 作业环境氧化铝粉尘时间加权几何平均浓度为 13.4mg/m3 (4.5～ 38.6mg/m3 ) ,铝接触组血清铝 (74 .0 8μg/L)和尿铝 (30 .5 1μg/L)浓度明显高于对照组 (血清铝 2 7.38μg/L、尿铝8.11μg/L) ;血清GSH Px活力降低 (分别为 95 .0 2U/ 0 .1ml和 14 2 .97U/ 0 .1ml) ,血清MDA含量增高 (分别为 6 .72nmol/L和 4 .2 8nmol/L) ,红细胞中SOD活力增高 (分别为 2 2 5 6 2 .39、195 2 3.2 8NU/ml) ,差异有显著性 (P <0 .0 0 1) ;血清铝、尿铝浓度皆与血清GSH Px活力呈负相关 ,且均与血清MDA含量及红细胞中SOD活力呈正相关。结论 铝接触工人脂质过氧化水平升高 。

Objective To study the effects of aluminum exposure on lipid peroxidation level in serum of workers exposed. Methods 65 workers from aluminum plant were selected to study the changes of aluminum concentration in serum and urine,serum GSH Px activity and serum MDA content and SOD activity in red blood cells. Results Geometric time weighted average of aluminum dust in workplace environment was 13.4 mg/m 3(4.5～38.6 mg/m 3).Compared with the control group,the exposed group showed that aluminum concentrations in serum(74.08 μg/L,27.38 μg/L) or urine(30.51 μg/L,8.11 μg/L) increased,serum GSH Px activity reduced(95.02,142.97 U/0.1 ml ),serum MDA content increased(6.72 nmol/L,4.28 nmol/L) and SOD activity in red blood cells increased(22 562.39,19 523.28 NU/ml)significantly( P <0.001).Aluminum concentrations in serum or in urine were correlated with serum GSH Px activity inversely,correlated with serum MDA content and SOD activity in red blood cells. Conclusion The levels of lipid peroxidation in workers exposed to aluminum increased.The increase of SOD activity would be a kind of compensation to prevent tissues from damage by lipid peroxidation.