悬饮宁治疗癌性积液的临床与实验研究

Clinical and Experimental Study on the Treatment of Carcinomatous Hydrops by"Xuanyin Decoction

为观察悬饮宁治疗癌性积液的疗效 ,将 93例癌性积液患者分成悬饮宁、悬饮宁方加化疗、和单纯化疗组 ,并进行 (2批 )动物实验研究。结果 :临床观察悬饮宁组、悬饮宁加化疗组、化疗组有效率分别为 87 5 %、96 7%、6 7 7%。前 2组与化疗组比较P <0 .0 1。实验研究结果发现 ,悬饮宁、悬饮宁加化疗组、化疗组、空白对照组腹水的形成率分别为 5 8 3%、2 5 0 %、33 3%、10 0 %。悬饮宁低、中、高剂量组、悬饮宁高剂量加化疗组、空白对照组S 180腹水瘤小鼠生存率分别为 2 5 %、41 7%、5 0 %、41 7%、8 3%。治疗后 1周及 2周对小鼠体重、腹围观察 ,悬饮宁、悬饮宁加化疗、化疗组与空白对照组比较差异显著 (P <0 .0 1或P <0 .0 5 )。提示悬饮宁对癌性积液有一定的疗效。

To observe the curative effects of 'Xuanyin Decoction'in the treatment of carcinomatous hydrops,93 patients were randomized into three groups:group A treated with'Xuanyin Decoction',group B with'Xuanyin Decoction'and chemotherapy,and group C with chemotherapy alone;moreover,animal experiments were conducted.Clinical observation showed that the effective rates in group A,B and C were 87 5%,96 7% and 67 7% respectively,with a striking difference between the former two groups and latter group,P<0 01;experimental study revealed that'Xuanyin Decoction'could control the weight and the production of ascites of mice and reduce the abdominal perimeter obviously.It is indicated that'Xuanyin Decoction'has some effects on carcinomatous hydrops.