针药结合对Graves'眼病患者血清眼外肌抗体依赖细胞介导的细胞毒作用

Effects of Acupuncture and Medicine on Serum Antibody-Dependent Cell-Mediated Cytotoxicity in Ocular Lateral Muscle of Patient with Graves' Ophthalmopathy

为探讨针药结合治疗Graves 眼病 (GO)的免疫学机理 ,5 4例GO患者随机分为治疗Ⅰ组、治疗Ⅱ组和对照组各 18例 ,测定治疗前后患者血清对人眼外肌抗体依赖细胞介导的细胞毒(ADCC)作用及血清抗眼肌膜抗体 (EMAb)的水平。结果 :治疗后患者血清对眼外肌的ADCC作用较治疗前明显降低 ,且治疗Ⅱ组低于对照组 (P <0 0 5 ) ;血清EMAb水平在针刺治疗后明显降低 (P<0 0 5 ,P <0 0 0 1) ;针刺Ⅱ组水平低于Ⅰ组和对照组 (P <0 0 1,P <0 0 0 1)。提示针药结合治疗Graves 眼病的眼肌损伤可能与降低EMAb ,减轻对眼外肌的ADCC有关。

To investigate the immunological mechanism of combined acupuncture and medicine in the treatment of Graves ophthalmopathy(GO),54 subjects were randomized into treatment group Ⅰ,treatment group Ⅱ and control group,18 cases in each.The serum antibody dependent cell mediated cytotoxicity(ADCC)and eye muscle antibody(EMAb)before and after treatment were measured.Results showed that,after treatment,ADCC reduced obviously,treatment group Ⅱ lower than control group(P<0 05);EMAb dropped significantly(P<0 05,P<0 001);treatment group Ⅱ lower than treatment group Ⅰ and control group( P <0 05, P <0 001).It is indicated that combination of acupuncture and medicine can reduce ADCC and EMAb in the treatment of GO.