冷烫液对小鼠的免疫毒性作用

Effects of perm lotion on immunity in mice

目的 研究冷烫液对小鼠免疫功能的影响。方法 选择体重 18～ 2 2g的雌性昆明种小鼠每组 10只 ,以冷烫液 12 5、2 5 0、10 0 0mg/kg灌胃染毒 3周后进行体液免疫、细胞免疫、非特异性免疫及免疫脏器重量测试。结果 2 5 0、10 0 0mg/kg剂量组的胸腺和脾脏重量明显低于对照组 (P <0 0 5 ,P <0 0 1) ,空斑形成细胞对数值、血清溶血素抗体体积、足跖厚度及碳廓清指数均低于对照组 (P <0 0 5 ,P <0 0 1)。

Objective To study the effects of perm lotion on immunity in mice. Methods 40 female Kunming mice, body weighed 18 22g, were randomly divided into 4 groups, After gavage of perm lotion at doses of 12.5mg/kg, 250mg/kg or 1 000mg/kg b.w.per day for 28 days successively, the humoral immunity, cytoimmunity, nonspecific immunity and immunopathology were tested. Results In 250mg/kg and 1 000mg/kg dose groups, all the thymus and spleen weight, the plaque forming cell count, serum hemolysin volume and toe thickness as well as carbon clearance index were significantly lower than those in control group ( P<0.05, P<0.01 ).Conclusion These results suggested that there are notable effects of perm lotion on immunity in mice.