硒蛋白对小鼠抗辐射损伤作用的研究

Resistance of selenium protein to the radiation harm in rats

研究硒蛋白 (Se protein)对小鼠抗辐射损伤作用 ,并与无机硒作了对比。结果表明 ,硒蛋白和无机硒均可显著抑制辐射所诱导的小鼠染色体畸变 (P <0 0 1) ,二者相比 ,硒蛋白的效应更为突出 (P <0 0 1)。两种硒还可有效抑制辐射对小鼠血液谷胱甘肽过氧化物酶 (GSH Px)活性及血液脂质过氧化物 (LPO)含量带来的影响 ,仍然是硒蛋白效应更为显著 (P <0 0 1)。Se 蛋白质 +60 Co组小鼠GSH Px活性 (49 3± 2 7)kU/L与空白组 (30 7± 2 1)kU/L相比P >0 0 5 ,LPO浓度 (13 6± 3 8)μmol/L与空白组 (11 7± 2 7) μmol/L相比P >0 0 5。硒蛋白还可有效抑制小鼠血液LPO的产生 。

To study the resistance of selenium protein to the radiation harm in rats, and compare the effect of selenium protein and inorganic selenium. The results showed that selenium protein and inorganic selenium could effectively inhabit the chromosome aberration caused by radiation( P <0 01),and selenium protein had a greater biochemical effect ( P <0 01). The two types of selenium could effectively inhabit the effects of GSH-Px and LPO in blood caused by radiation, and there was the most significant biochemical effect in selenium protein ( P <0 01). Comparison was made between effects of GSH-Px in Se-protein + 60 Co group (49 3±2 7 kU/L) and control group (30 7±2 1 kU/L)( P >0 05), and LPO in the Se-protein+ 60 Co group (13 6±3 8 μmol/L) and opposition group(11 7±2 7 μmol/L)( P >0 05). Se-protein could effectively reduce quantity of LPO, and there is a positive correlation between dosage and inhibition.