慢性乙型肝炎患者TNF-α和IL-6的变化及双利肝对其影响

Values of TNF-α and IL-6 in patients with chronic hepatitis B and effects of Shuangligan on cytokines

目的 探讨TNF -α、IL - 6在慢性乙肝不同阶段的作用及双利肝对于两种细胞因子的影响。方法 5 5例慢性乙肝患者在治疗前测定血清TNF -α、IL - 6水平及肝功能。在一般保肝治疗基础上口服双利肝 ,在治疗前后测定血清TNF -α、IL - 6水平及肝功能。结果 随着肝功能损害加重 ,TNF -α、IL - 6水平显著升高 (P <0 0 1,P <0 0 5 ) ,经过双利肝治疗 ,患者转氨酶、胆红素、TNF -α水平明显下降 (P <0 0 1) ,IL - 6水平略有上升但无显著性差异 (P >0 0 5 )。结论 慢性乙肝病程中 ,TNF -α与肝细胞坏死程度有关 ,可作为病情轻重的判别指示。IL - 6与肝脏损伤过程有关。双利肝可明显降低慢性乙肝患者TNF -α水平 。

Objective To determine the actions of TNF α and IL 6 in the different states of chronic hepatitis; the effect of Shuangligan, a Chinese medicine (radix salviae miltiorrhizae, rhubarb etc.) on the two cytokines. Methods Before therapy, RIA was performed in 55 chronic hepatitis B patients to determine the serum levels of TNF α and IL 6; before and after taking orally Shuangligan for 30 days, RIA was performed in 30 patients with chronic hepatitis B to determine the serum levels of TNF α and IL 6. Results TNF α and IL 6 levels increased significantly, as liver function damage became worse and there was positive correlation between two cytokines. After taking Shuangligan the level of TNF α reduced significantly with liver function improvement, but the level of IL 6 had no significant change. Conclusion In the course of chronic liver disease, TNF α is a guideline to estimate the seriousness of liver inflammatory process. IL 6 has different effects in chronic liver disease process. Shuangligan can reduce the level of TNF α in chronic hepatitis B patients and improve the liver function.