虎茵汤对四氯化碳致小鼠急性肝损伤的保护作用

Protective Effect of Huyin Decoction on Acute Hepatic Injury Induced by CCl_4 in Mice

目的:观察不同浓度的虎茵汤对四氯化碳(CCl_4)致小鼠急性肝损伤的保护作用。方法:采用腹腔注射CCl_4致小鼠急性肝损伤为模型,测定高、低剂量的虎茵汤对肝损伤ALT、AST值的影响,同时对肝组织进行病理组织学检查。结果:虎茵汤能够明显降低CCl_4致小鼠肝损伤血清ALT、AST值升高(P<0.01),减轻CCl_4对肝脏细胞的病理损伤。结论:虎茵汤对CCl_4致急性肝损伤具有一定的保护作用。

Objective: To observe the protective effect of Huyin decoction on acute hepatic injury induced by CCl4 in mice. Methods: The model of acute hepatic injury induced by CCl4 was used. The levels of ALT and AST in serum were detected. And histopathology of liver was observed. Results: Huyin decoction could decrease ALT and AST in serum and heptic histopathological inury of the acute heptic injury mice. Conclusion: Huyin decoction possessed protective effect on acute hepatic injury in mice.