44例牙源性纤维瘤临床病理分析

Clinicopathological study on 44 cases of odontogenic fibroma

目的 研究牙源性纤维瘤的临床病理特点。方法 按世界卫生组织（ＷＨＯ）１９９２年牙源性肿瘤分类标准对 ４４例牙源性纤维瘤的临床病理特点及生物学行为进行回顾性研究。结果 本组 ４４例中，女３１例，男１３例。发病年龄２～７０岁，平均２９岁。中心型５例，周边型３９例。上颌１９例，下颌２５例。Ｘ线及手术中见４例牙槽骨明显破坏。术后有４例复发。组织学上表现为ＷＨＯ型３９例、单纯型４例和牙源性颗粒细胞瘤１例。肿瘤无明显包膜，边界尚清。结论 牙源性纤维瘤不是单一性肿瘤，组织学上表现为ＷＨＯ型、单纯型和牙源性颗粒细胞瘤。诊断时应与增殖性牙滤泡、粘液瘤等相鉴别。

Objective To investigate the characteristics of clinicopathology of odontogenic fibroma. Methods According to WHO(1992) classification of odontogenic tumours, 44 cases of odontogenic fibroma were studied clinicopathologically. Results 31 cases were involoved in female, 13 cases male. 10 cases were found in maxilla, 25 cases in mandible. 5 cases were central odontogenic fibroma. 39 cases were perpheral odontogenic fibroma .Histologically, 39 cases were diagnosed as WHO type, 4 cases simple type, 1 case giant cell odontogenic fibroma. The mild destruction of alveolar hone were found during operation and X ray examination. A definite capsule could not be identified in the tumour, but the border were usually well demarcated, conclusion Histologcally odontogenic fibroma shows varied types of lesions. It could be WHO type, simple type and granular cell odontogenic fibroma. Diagnostically it should be differentiated from hyperplastic dental follicle, myxoma and so on.