大肠癌组织p16蛋白表达与临床病理关系的探讨

Expression of P16 protein in colorectal carcinoma tissue and its correlation with clinical pathology

目的 研究大肠癌组织P 16蛋白表达及其与临床病理学特征的关系?方法 采用免疫组织化学ABC法检测53例大肠癌组织中P 16蛋白的表达?结果 大肠癌组织中P 16蛋白表达率为35.8%,P 16表达随肿瘤分化程度的降低而减弱(P<0.05) ?Dukes分期,AB期P 16表达率高于CD期,分别为51.5%和10.0%,有显著性差异(P<0.05)?结论 P 16蛋白表达缺失与大肠癌发生有关,并可作为临床判断肿瘤分化程度及Dukes分期的重要参考指标?

Objective To investigate the expression of p16 protein in colorectal carcimoma tissue and its correlation with clinicopathological featares. Methods The expression of p16 protein was detected by ABC immunohistohistochemical method in 53 cases of colorectal carcinoma.Res ults The detection rates of p16 protein was 35.8% in colon cancer.according to Dukes staging,the positive rate in A,B grades (51.5%) was higer than the rate in C,D grades (10.0%).The expression of p16 protein was reduced with the malignancy of cancerous tissues (P<0.05) .Conclusion The mutation and loss of p16 gene was closely related to the occurrence and development of colorect cancer.p16 gene assay plays an important role in the estimation of differentiation degree of cancerous tissues and Dukes stages.