急性脑梗塞始发状态火热证与垂体-肾上腺轴激素的关系研究

Study on Relationship Between Heat S yndrome in TCM and Pitu-itariuno -Adrenal Axis Hormones in I nitial Condition of Acute Cerebral Infarction

目的探讨急性脑梗塞(ACI)始发状态火热证与垂体-肾上腺轴激素犤促肾上腺皮质激素(ACTH)、皮质醇(CS)犦的关系。方法采用中风病专家经验辨证量表对151例ACI患者的始发状态进行证候评分,同时利用放射免疫分析(RIA)法测定ACTH、CS含量,再按证候评分将患者分成火热证组与非火热证组,对比2组患者ACTH、CS的变化水平,并与健康人组(60例)作对照。结果(1)火热证组的ACTH、CS水平显著地高于非火热证组(P<0.001),火热证组及非火热证组的ACTH、CS含量与正常健康人组比较也呈上述变化(P<0.001);(2)火热证组患者的火热证评分与ACTH、CS含量呈正相关关系(r=0.51、t=3.19和r=0.50、t=3.11)。结论火热证与ACTH、CS具有正相关关系,其升高水平可作为判定ACI始发状态火热证与非火热证的微观指标。

Objective:To find the relationship between Hea t syndrome and changes of pituitariuno -adrenal ax is hormones(adrenocoticotropic hor-mone ACTH,corticosteroid CS)levels at initial condition of acute cere-bral infarction(ACI ).Methods:Using the table of syndrome quantita tive diagnosis formulated according to e xperiences of nationwide apoplectic experts,we scored the patient ' s syndrome at initial condition for 151cases,at the same time the levels of p lasma ACTH and CS were deter-mined by RIA.According to the score o f their syndrome the patients were divided into two groups,one was Heat syndrome,the other is Non -Heat syndrome.Results:It showed that①The levels of ACTH and CS in Heat syndrome group were very marked ly higher than those in Non -Heat syndrome group(P<0.001);the levels in both groups were also significantly higher than those in h ealthy subjects(P<0.001);②Posi-tive correlationship between the sc ores of the 35Heat syndrome cases and the levels of ACTH and CS(r =0.51?t =3.19VS r =0.50?t =3.11)existed.Conclusion:The results demonstrate that the levels ofACTH and CS in initial condition of ACI can be regarded as index to differentiate Heat syndrome from No n -Heat syndrome.