阻塞性睡眠呼吸暂停与胃食管反流的关系

THE RELATIONSHIP BETWEEN OBSTRUCTIVE SLEEP APNEA AND GASTRO-ESOPHAGEAL REFLUX

目的 :探讨阻塞性睡眠呼吸暂停 (OSA)与胃食管反流 (GER)的关系及经鼻持续气道正压通气的疗效。方法 :2 2例典型 OSAS症状患者同步进行多导睡眠图 (PSG)食管 p H监测 ,对并有 GER患者行连续 10晚经鼻持续气道正压通气 (n C-PAP)治疗 ,后复查 PSG和食管 p H。结果 :2 2例患者均为 OSA,有 11例为 OSAS并 GER,其中 7例进行 10晚 n CPAP治疗后 ,呼吸暂停低通气指数 (AHI)从 36 .5 4± 2 1.35减少到 10 .0 3± 4.85 (P <0 .0 5 ) ;De Meester评分从 5 5 .5 6± 2 9.5 9减少到 2 2 .30± 2 3.2 3(P <0 .0 5 ) ;卧位 p H<4时间百分比从 18.71± 17.0 8减少到 4.37± 6 .6 2 (P <0 .0 5 ) ;酸反流次数也明显减少 (P <0 .0 5 )。结论 :GER与 OSA相关 ,OSA可能是 GER的原因之一 ,对 OSA并 GER者进行 n

Objective:To study the relationship between gastroesophageal reflux (GER) and obstructive sleep apnea (OSA) and the therapeutic use of nasal continuous positive airway pressure (nCPAP) Methods:24 hour esophageal pH monitoring and polysomnography (PSG) were performed simultaneously in 15 cases with typical symptoms of obstructive sleep apnea syndrom (OSAS) The patients with GER were treated with nCPAP for ten nights,and then the same tests above were repeated Results:10 of the 15 patients with OSA showed GER 7 of the 10 patients took the nCPAP, and AHI was decreased from 36 54±21 35 before nCPAP to 10 03±4 85 after nCPAP (P<0 05),DeMeester scoring from 55 56±29 59 to 22 30±23 23(P<0 05),the percentage of supine acide exposure time from 18 71±17 0 to 4 37±6 62 (P<0 05),total times of acid reflux were reduced significantly Conclusion: Our results suggest that OSAS may predispose to GER nCPAP effectively reduced GER in those with gastroesophageal reflux