贞芪扶正胶囊抗大鼠肝癌机制的研究

Study on the Mechanisms of A-L Tonic Capsule Inhibiting Rat Hepatocellular Carcinoma

以二乙基亚硝胺诱发大鼠肝癌为模型 ,运用免疫学和病理学技术观察贞芪扶正胶囊对 4组诱癌大鼠血清白细胞介素 2、肿瘤坏死因子浓度 ,自然杀伤细胞活性及肝脏形态改变的影响。结果显示 :服用贞芪扶正胶囊 8周后再加致癌剂的大鼠 ,其自然杀伤细胞活性明显高于单纯服用致癌剂的大鼠 (P<0 .0 1) ,血清白细胞介素 2、肿瘤坏死因子浓度与单纯致癌组相比有增高趋势 ,致癌剂对肝脏的毒性损伤也明显低于其它实验组。提示贞芪扶正胶囊可增强化学诱癌时大鼠的抗癌能力 ,减轻致癌剂对肝脏的毒性损伤和延缓肝癌发生。

By using immunological and pathological methods, the influence of A-L tonic capsule on serum concentrations of IL-2 and TNF, NK cell activity as well as liver morphological change was observed in 4 different experimental groups of rats during hepatocarcinogenesis induced by diethylnitrosamine (DENA). The results showed that NK cell activity of rats in the group A, in which the rats were preventively administered by A-L tonic capsule for 8 weeks followed by DENA, was markedly higher than in the group D, in which the rats were only given DENA, P<0.01. Serum concentrations of IL-2 and TNF in the group A had a tendency to increase as compared with that in the group D. Liver tissue toxic injury induced by carcinogen in the group A was also milder than that in other experimental groups. It was indicated that A-L tonic capsule could enhance anti-cancer ability of the rats, reduce liver tissue toxic injury induced by carcinogen and postpone hepatocarcinogenesis.