人乳头瘤病毒感染与女性生殖器尖锐湿疣发病的相关性

Study on Relationship between Human Papilloma Virus Infection and Condyloma Acuminate

为探讨人乳头瘤病毒 (HPV)感染与女性生殖器尖锐湿疣的相关性 ,随机选择协和医院性病专科门诊有临床疣者 30例 (A组 ) ,无临床疣者 5 3例 (B组 ) ,采用 PCR技术检测 HPV。另从 HPV阳性者中选择 36例 ,采用 PCR技术检测淋球菌 (NG)、沙眼衣原体 (CT)及解脲支原体 (U U)。结果 A组 HPV阳性率显著高于 B组 (P<0 .0 1)。 36例 HPV阳性者 16例为 NG或 CT或 U U感染 ,而非尖锐湿疣 ,6例为尖锐湿疣与 NG或 CT或 U U混合感染。提示为了提高尖锐湿疣的正确诊断率 ,须将传统的病理组织学检查与现代的 PCR技术结合运用。

In order to study the relationship between the infection of human papilloma virus (HPV) and the condyloma acuminate (CA), patients were divided into two groups randomly: group 1 with clinical condyloma (n=30) and group 2 without clinical condyloma (n=53). Polymerase chain reaction (PCR) was used to detect HPV in cervical canal discharge. Gonococcus (NG), C.trachomatis (CT) and Ureaplasma urealyticum (UU) were examined by PCR in 36 patients selected from those with positive HPV. The positive rate of HPV in the group 1 was significantly higher than in the group 2 (P<0.01). Among 36 cases with positive HPV, 16 were diagnosed as having infection of NG, CT or UU, but not having CA; 6 having co-infection of CA and NG or CT or UU. It was suggested that in order to increase the correct diagnosis rate, it was necessary to combine the traditional histological examination with the current PCR technique.