尿微量蛋白检测对老年高血压病肾损害的早期诊断价值

Diagnostic value of urine trace protein test of the early kidney lesion among aged hypertension

目的 :探讨尿微量蛋白水平检测对老年高血压肾损害的早期诊断价值。方法 :收集 95例老年原发性高血压(EH)患者晨尿、空腹静脉血 ,采用酶联免疫法测定尿微量白蛋白 (micro- albumin,MA)及血、尿β2 微球蛋白 (β2 -MG) ,并测定血尿素氮 (BUN)、肌酸 (Cr) ,肾联检阳性为尿 MA,血、尿 β2 - MG中任何一项指标高于正常值。结果 :单项指标阳性率 :β2 - MG 71.5 7% ,尿β2 - MG 6 8.42 % ,尿 MA 5 3.6 8% ,多项指标联检阳性率 85 .2 6 %均高于尿常规 (14.73% )和 BUN、Cr阳性率 (2 9.47% ) ,差异非常显著 (P<0 .0 0 1)。EH2、 3级极高危患者血、尿微量蛋白肾联检总阳性率 10 0 %。结论 :血、尿微量蛋白在老年性高血压病肾功能受损时较肾功能指标 BU N、Cr改变出现早 ,是诊断肾功能早期损害的敏感指标。

Objective:To study the diagnostic value of renal trace protein test on early kidney lesion in aged patients with hypertension.Methods:Morning urine,vein blood at empty stomach of 95 aged essential hypertension(EH) patients were collected.Urine microalbumin(MA),both urine and blood β 2-MG were assayed with ELISA,blood BUN,Cr also assayed;when any of these index(MA,blood,urine β 2-MG) was positive,it was regarded as urine\|linked assay positive.Results:Positive rate of blood β 2-MG,urine β 2-MG,MA was 71.57%,68.42%,53.68% respectively,positive rate of urine-linked assay was 85.26%.Positive rate of these index was higher than urine routine test(14.73%),BUN?Cr(29.47%)( P< 0.001);positive rate of urine-linked assat was 100% in patients with 2 and 3 stage EH.Conclusion:MA,blood?urine β 2-MG levels have earlier alteration than chaneg of BUN,Cr in aged EH patients with early kidney lesion.