周围型肺癌CT征象与PCNA蛋白表达之间关系的研究

Study on the relationship between CT appearance and expression of PCNA protein in peripheral lung cancer

目的 :研究周围型肺癌PCNA蛋白表达与CT表现之间的关系。方法 :应用链菌素亲生物素—过氧化物酶法(SP法 )检测 5 3例经病理证实的周围型肺癌组织中PCNA蛋白的表达 ,并分析其与CT征象间的关系。结果 :PCNA蛋白表达与肿瘤分化程度、恶性度、大小、深分叶征、淋巴结转移、空洞征和胸膜凹陷征有关 ,与毛刺征无关。结论 :肺癌组织分化越低其PCNA表达越高 ,CT征象中肿瘤≥ 3cm、深分叶征、淋巴结转移。

Objective:To investigate the correlation between CT appearance and expression of PCNA protein in peripheral lung cancer.Methods:The expression of PCNA protein was examined by SP immunohistochemical technique in 53 cases of peripheral lung cancer proved by pathology,and the relationship between the expression of PCNA protein and CT appearance was analyzed.Results:The expression of PCNA protein was correlated with tumor size,deep lobulation,mediastinal lymph node metastasis,frank cavitation and pleural indentation( P <0.05 -0.01 ),but not with spiculation( P >0.05).The expression of PCNA protein was also correlated with the degree of the tumor cell differentiation and malignancy( P <0.01).Conclusion:The CT features of peripheral lung cancer with diameter more than 3cm,deep lobulation,lymph node metastasis,frank cavitation and pleural indentation indicate higher degree of malignancy and proliferative activity of tumor cells.