摘要
目的 :观察长春瑞滨 (NVB)、吡柔比星 (THP)联合化疗治疗晚期乳腺癌疗效。方法 :2 5例术后复发转移 ,16例有 2处以上部位转移 ,且全部为复治的Ⅳ期患者。NVB 2 5mg/m2 ,静脉冲入 ,第 1、8天 ;THP 4 0mg/m2 ,静脉冲入 ,第 2天 ,2 1天为一周期。结果 :完全缓解 2例 ,部分缓解 12例 ,有效率为 5 6 %。主要毒副作用为骨髓抑制和静脉炎。白细胞减少为 10 0 % ,其中Ⅲ、Ⅳ度达 6 0 %。结论 :NVB +THP联合作为二线化疗方案治疗晚期乳腺癌疗效较好 。
Objective:To evaluate the efficacy and toxicity of NVB and THP combined chemotherapy(NT regimen) on advanced breast cancer.Methods:Twenty-five postoperation local relapsed and distant metastasized patients with breast cancer were treated by NT combination chemotherapy, All of them had previously been treated and belong to the stage Ⅳdisease according to 1989 staging criteria of UICC. VRB was given at a dose of 25 mg/m 2 on day 1,8, THP 45mg/m 2 day 2 intravenously every 3 weeks.Results:There were 2 complete responses and 12 partial responses. The overall response rate was 56%. The most common toxicities seen were myelosuppression and phlebitis. Leukopenia was observed in all patients, and Grade 3 and 4 leukopenia in most of patients (60%).Conclusion:The NT combination chemotherapy is effective for advanced breast cancer as second line chemotherapy regimen.
出处
《临床肿瘤学杂志》
CAS
2002年第1期69-70,共2页
Chinese Clinical Oncology
