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p27^(kip1)基因与肿瘤关系的研究进展 被引量：6

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摘要 该文对p27kip1基因与肿瘤关系的研究进展进行阐述,为研究肿瘤发生、发展、诊断及治疗提供了一定的科学依据。
作者 岳辉 于皆平
机构地区 武汉大学人民医院
出处 《中国临床康复》 CSCD 2002年第4期550-551,共2页 Chinese Journal of Clinical Rehabilitation
关键词 P27^KIP1基因 肿瘤 基因疗法
分类号 R730.54 [医药卫生—肿瘤]
  • 相关文献

参考文献13

  • 1MATSUMOTO M, FARIHATA M, OHTSUKI Y, et al. Immunohistochemical characterization of p57kip2 expression in human esophageal squamous cell carcinoma[J]. Anticancer Res,2000,20(10):1947-1952.
  • 2TOYOSHIMA H,HUNYER T. p27, a novel inhibitor of G1 cyclin-CDK protein kinase activity,is related to p21[J].Cell ,1994; 78(1) :67-74.
  • 3NAKAYAMA K, ISHIDA N, SHIRANE M, et al. Mice lacking p27kip1 display increased body size ,multiple organ hyperplasia, retinal dysplasia, and pituitary tumors[J].Cell .1996; 85(5): 707-720.
  • 4SPIRIN KS, SIMPSON F, TAKEUCHI S, et al. p27kip1 mutation found in breast cancer[J].Cancer Res, 1996;56:2400-2404.
  • 5XPOLYAK K, LEE MONG HONG, ERDJUMENT BROMAGE H, et al. Cloning of p 27 kip1,a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals[J] .Cell, 1994;78(1):59-66.
  • 6KIYOKAMA H, KINEMAN RD, MANOVA TODOROVA KO, et al. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27kip1[J].Cell, 1996;85(5):721-732.
  • 7KATAYOSE Y, KIN M, BAKKAR AN, et al. Promoting apoptosis:A novel activity associated with the cyclin-dependent kinase inhibitor p27[J].Cancer Res, 1997;57(24):5441-5445.
  • 8TAKEICHI S, MORI N, KOIKE M, et al. Frequent loss of heterozygosity in region of the KIP1 locus in non-small cell lung cancer :evidence for a new tumor suppressor gene on the short arm of chromosome 12[J].Cancer Res,1996, 56(4): 738-740.
  • 9PIETENPOL JA, BOHLANDER SK, SATO Y, et al. Assigment of human p27kip1gene to 12p13 and its analysis in leukemias[J]. Cancer Res,1995,55(6):1206-1210.
  • 10KAWAMATA N, MOROSETTI R, MILLER, et al. Molecular analysis of the cyclin-dependent kinase inhibitor gene p 27 kip1 in human malignancies[J].CancerRes,1995,55(11):2266-2269.

同被引文献31

  • 1Ohtani M, Isozaki H, Fujii K, et al. Impact of the expression of cyclin-dependent kinase inhibitor p27^kipl and apoptosis in tumor cells on the over all survival of patients with non - early stage gastric carcinoma. Cancer 1999; 85 (8): 1711 - 7.
  • 2Naruse I, Hoshino H, Dobashi K, et al. Over-expression ot p27^kipl induces growth arrest and apoptosis mediated by changes of pRb expression in lung cancer cell lines. Int J Cancer 2000; 88 (3):377 -83.
  • 3Hirano K, Zeng Y, Hirano M, et al. Sequence requirement for nuclear localization and growth inhibition of p27kiplR, a degradation-r esistant isoform of p27^kip1. J Cellular Biochemistry 2003; 89:191 - 202.
  • 4Singh SP, Lipman P, Goldman H, et al. Loss or altered subcellular localization of p27 in barrett's associated adenocarcinoma. Cancer Res 1998; 58: 1730- 5.
  • 5Sgambato A, Ratto C, Faraglin B, et al. Reduced expression and altered subcellular localization of cyclin-dependent kinase inhibitor p27^kipl in human colon cancer. Mol Carcing 1999; 26:172 - 97.
  • 6Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosme 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15:356 -62.
  • 7Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275:1943-7.
  • 8Besson A, Robbins SM, Yong VW. PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis. Eur J Biochem 1999; 263:605-11.
  • 9Soria JC, Lee JI, Wang L, et al. Lack of PTEN expersion in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 2002; 8 (5):1178 -84.
  • 10Lee HY,Suh YA,Kosmeder JW,et al Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells Clin Cancer Res 2004;10(3):1074-9.

引证文献6

二级引证文献18

中国临床康复
2002年 第4期

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