参附注射液治疗不稳定性心绞痛的疗效观察

Evaluation of ginseng and monkshood parenteral solution in patients with unstable angina pectoris

目的 观察参附注射液 (GMPS)治疗冠心病不稳定性心绞痛的疗效 .方法 采用 GMPS随机对 30例冠心病不稳定性心绞痛患者 2 wk治疗 ,另设 30例冠心病不稳定性心绞痛患者为对照组 .对治疗前后患者甲襞微循环等指标进行测定 ,并观察症状及生命体征 .结果 与对照组相比 ,GMPS能更明显地增加不稳定性心绞痛患者甲襞微循环的管襻密度[(7.0± 1.1)条· mm- 2 vs (6 .0± 1.0 )条· mm- 2 ,P<0 .0 1]、管襻直径 [输入枝 (4 .5± 0 .6 ) μm vs(3.8± 0 .5 ) μm,输出枝 (6 .8± 0 .8)μm vs (5 .9± 0 .7)μm,P<0 .0 1]、管襻长度[(2 36± 5 1) μm vs(16 2± 6 2 ) μm,P<0 .0 1]和血流速度[(10 10± 2 2 1)μm· s- 1 vs (789± 195 )μm· s- 1 ,P<0 .0 1],减少交错 [(1.6± 0 .6 )条· m m- 2 vs(2 .0± 0 .4)条· mm- 2 ,P<0 .0 1]和畸形 [(0 .3± 0 .1)条· mm- 2 vs (0 .5± 0 .1)条·mm- 2 ,P<0 .0 1]的管襻数 ,更明显改善红细胞的聚集性 (治疗后轻度及正常为 16 / 30 vs8/ 30 ,P<0 .0 5 ) .结论

AIM To investigate the effect of ginseng and monkshood parenteral solution administration on patients with unstable angina pectoris. METHODS Sixty CHD pa tients were randomized into 2 groups: Ginseng and monkshood parenteral and control. Nail fold microcirculation, vital signs were measured. RESULTS By comparison with control, the density (7.0±1.1 vs 6.0±1.0 strips·mm -2 , P < 0.01), diameter(4.5±0.6 vs 3.8±0.5 μm in inlet twig, 6.8± 0.8 vs 5.9±0.7 μm in output twig, P <0.01), length (236±51 vs 162±62 μm, P <0.01 )of the capillary loop and blood velocity (1010±221 vs 789±195 μm·s -1 , P <0.01) in ginseng and monkshood parenteral group were increased more significantly; The intersection(1.6±0.6 vs 2.0±0.4 strips·mm -2 , P <0.01) or abnormal(0.3±0.1 vs 0.5±0.1 strips·mm -2 , P <0.01) capillary loop quantities and the aggregation of red cell(16/30 vs 8/30 cases in mild or normal, P < 0.05) were decreased more obviously. CONCLUSION Ginseng and monkshood solution plays therapeutic role by improving microcirculation of coronary artery in patients with unstable angina pectoris.