不同药物用于自控硬膜外镇痛的比较

Comparison of Different Drugs in PCEA

目的 比较不同药物用于自控硬膜外镇痛 (PCEA)的临床效果和不良反应发生率。方法 90例病人随机分成 3组 ,A组 (n =30 )PCEA药液为 0 15 %～ 0 2 %布比卡因 ;B组 (n =30 )PCEA药液为 0 15 %～0 2 %布比卡因 +吗啡 2～ 5mg ;C组 (n =30 )PCEA药液为 0 15 %～ 0 2 %布比卡因 +芬太尼 0 1～ 0 3mg。结果 3组镇痛优良率分别为 2 6 6 %、83 3%、80 %。B组和C组镇痛效果明显优于A组 (P <0 0 1)。恶心、呕吐、排尿困难不良反应发生率B组最高。结论 布比卡因复合芬太尼用于硬膜外镇痛效果较好、不良反应较少 。

Objective To compare clinical effects and incidence of side effect of different drugs in PCEA. Methods 90 cases were divided into 3 groups in random, the PCEA drug of group A (n=30)was 0.15%～0.2% bubicraine; drugs of group B(n=30)were 0.15%～0.2% bubicraine and morphine 2～5 mg; drugs of group C were 0.15%～0.2% bubicraine and fentanyl 0.1～0.3mg. Results The effect rate of group A, B and C were 26.6%, 83.3% and 80% relatively. The effects of group B and C were better than group A (P<0.01>obviously. The incidence of vomiting, nausea, dysuria was the highest in group B. Conclusion To be a effective and safe method of analgesia, bubicrane and fentanyl can do good to PCEA, and bring little side effects.