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以EB病毒为靶的基因治疗策略 被引量：3

Potential strategy in gene therapy:EB virus as a target
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摘要 EB病毒与多种人类肿瘤的发生有关 ,根据 EB病毒感染的特点 ,近年来发展了以 EB病毒为靶的基因治疗的基本策略。本文综述了这一研究领域的最新进展。
作者 王海 曹亚
机构地区 中南大学湘雅医学院肿瘤研究所
出处 《国外医学（肿瘤学分册）》 2002年第1期9-11,共3页 Foreign Medical Sciences (Cancer Section)
关键词 EB病毒 EB病毒相关肿瘤 基因治疗 EB病毒核抗原1 特异蛋白潜伏膜蛋白1
分类号 R456 [医药卫生—治疗学]
  • 相关文献

参考文献14

  • 1Ragoczy T, Heston L, Miller G. The Epstein-Barr virus Rta protein activates lyric cycle genes and can disrupt latency in B lymphoeytes[J]. J Virol, 1998, 72(10): 7978-7984.
  • 2Westphal EW, Blackstock W, Feng W, et al. Activation of lytic Epstein-Barr virus (EBV) infection by radiation and sodium butyrate in vitro and in vivo: a potential method for treating EBV-positive malignancies[J]. Cancer Res, 2000, 60(20): 5781-5788.
  • 3Morre SM, Cannon JS, Tanhehco YC, et al. Induction of epstein-barr virus kinases to sensitize tumor cells to nucleoside analogues[J]. Antimicrob Agents Chemother, 2001, 45(7): 2082-2091.
  • 4Westphal EW, Mauser A, Swenson J, et at. Induction of lyric Epstein-Barr virus infection in EBV-associated malignancies use in adenovirus vectors in vitro and in vivo[J]. Cancer Res, 1999, 59(7): 1485-1491.
  • 5Sunita Z, Elizabeth HG. Epstein-Barr viral latency is disrupted by the immediate early BRLF1 protein through a cell specific mechanism[J]. Proc Natl Acad Sci USA, 1996, 93(17): 9194-9199.
  • 6John LY, Sarah MC, Jacqueline MB. The minimal replicator of Eptein-Barr virus orip[J]. J Virol, 2000, 74(10): 4512-4522.
  • 7Rogers RP, Ge JQ, Holley GE, et al. Killing Epstein-Barr viruspositive B lymphocytes by gene therapy: comparing the efficacy of cytosine deaminase and herpes simplex virus thyrmidine kinase[J]. Hum Gene Ther, 1996, 7(18): 2235-2245.
  • 8Jean GJ, Gordon S, Jan M, et al. Use of Epstein-Barr virus nuclear antigen-1 in targeted therapy of EBV-associated neoplasia[J]. Human Gene Therapy, 1996, 7(5): 647-653.
  • 9Kenney S, GE JQ, Eva M, et al. Gene therapy strategies for treating Eptein-Barr virus associated lymphomas: comparison of two different Epstein-barr virus based vectors[J]. Human Gene Therapy, 1998, 9(8): 1131-1141.
  • 10Lee CG, Vieira WD, Pastan Ⅰ, et al. An episomally maintained mdrl gene for gene therapy[J]. Hum Gene Ther, 2001, 12(8): 945-953.

二级参考文献4

  • 1Hu L F，Oncogene，1993年，8卷，1575页
  • 2韩金祥，国外医学肿瘤学分册，1993年，20卷，341页
  • 3Chen M L，Oncogene，1992年，7卷，2131页
  • 4鄂征，组织培养技术（第2版），1988年

共引文献8

同被引文献16

  • 1OHSHIMA K, SUZUMIYA J, KANDA M, et al. Genotypie and phenotypic alterations in Epstein - Barr virus - associated lymphoma[J]. Histopathology, 1999, 35(6) : 539 -550.
  • 2TOSATO G, TATA K, ANGIOLILLO A L, et al. Epstein - Barr virus asan agent of hemato logical disease [ J ]. Balliere' s Clin Hematol, 1995, 8 (1): 165-199.
  • 3GAN R, YIN Z, LIU T, et al. Cyclosporine A effectively inhibits graft - versus - host disease during development of Epstein - Barr virus - infected human B cell lymphoma in SCID mouse [ J ]. Cancer Sci, 2003, 94(9): 796- 801.
  • 4ZETTERBERG H, BORESTROM C, NILSSON T, et al. Multiple EBNA1 -binding sites within oriPI are required for EBNAI -dependent transactivation of the Epstein - Barf virus C promoter[ J ]. Int J Oncol, 2004, 25 (3) : 693 - 696.
  • 5GULLEY M L, GLASER S L, CRAIG F E, et al. Guidelines for interpreting EBER in situ hybridization and LMP1 immunohistochemical tests for detecting Epstein - Barr virus in Hodgkin lymphoma[J]. Am J Clin Pathol, 2002, 117(2) : 259 -267.
  • 6NOORALI S, NASIR M I, PERVEZ S. Characterization of angio- immunoblastic T- cell lymphomas (AILT) and its association with Epstein - Barrvirus ( EBV ) in Pakistanipatients [ J ]. Coll Physicians Surg Pak, 2005, 15(7) : 404 -408.
  • 7BOLLARD C M, COOPER L J, HESLOP H E. Immunotherapy targeting EBV - expressing lymphoproliferative diseases [ J ]. Best Pract Res Clin Haematol, 2008, 21 (3) : 405 -420.
  • 8孙燕,周际昌.临床肿瘤内科学[M].北京:人民卫生出版社,2003.336-348.
  • 9汤钊献.现代肿瘤学[J].上海:复旦大学出版社,2003:628.
  • 10TERAMOTO N,NAEDA A,KOBEYASHI K,et al.Epstain-Barr virus infection to Epstain-Barr virus-negative nasopharyngeal carcinoma cell line TW03 enhance its tumorigenicity[J].Lab Invest,2000,80:303-312.

引证文献3

二级引证文献3

国外医学（肿瘤学分册）
2002年 第1期

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