法莫替丁、呋喃唑酮、阿莫西林根除幽门螺杆菌感染

Eradication of Helicobacter pylori with famotidine,furozolidonum and amoxicillin

目的 :探索一种疗效高、剂量小、疗程短、价廉的根除幽门螺杆菌 (Hp)的方案。 方法 :将 90例Hp阳性、内镜确诊为活动期十二指肠溃疡的患者随机分为两个治疗组 :A组给予法莫替丁 2 0mg、呋喃唑酮 1 0 0mg、阿莫西林 50 0mg ,均为每天 2次 ,共 1周。B组给予奥美拉唑 2 0mg ,每天 1次 ;阿莫西林 50 0mg,每天 4次 ;甲硝唑 40 0mg ,每天 3次 ,共 2周。在治疗前 3天内和治疗后 4～ 6周内 ,分别经内镜在胃窦和胃体取活检标本 ,采用快速尿素酶试验及组织学检查方法检测Hp ,并观察十二指肠溃疡愈合情况。结果 :A、B两组Hp根除率分别为 91 .1 %和 93 .6 % (P >0 .0 5) ,4周溃疡愈合率分别为 84.4 %和 86 .9% (P>0 .0 5) ,两组药物不良反应发生率为 2 0 .0 %和 46 .7% (P <0 .0 1 )。结论 :法莫替丁、低剂量呋喃唑酮和低剂量阿莫西林组成的三联一周疗法 ,具有根除Hp率高、服药方便、不良反应少。

Objective:To evaluate the effect of the triple therapy of famotidine,furozolidonum and amoxicillin on the eradication of Helicobacter pylori (Hp) infection in patients with duodenal ulcer.Methods:Ninety patients with Hp infected duodenal ulcer were divided into two groups at random.Group A(45 cases) received famotidine(20 mg),furozolidonum(100 mg) and amoxicillin(500 mg) twice daily for one week.Group B were treated with omeprazole(20 mg every day),amoxicillin(0.5 mg 4 times daily) and metronidazole(400 mg 3 times daily) for two weeks.Hp status and the healing of duodenal ulcer were assessed by endoscopy,rapid urease test and histology of gastric biopsy specimens taken from both the antrum and corpus 3 days before therapy and 4 to 6 weeks after completion of treatment.Results:The eradication rates in group A and B were 91.1% and 93.6%( P >0.05),respectively.The healing rates of duodenal ulcer in group A and B after treatment were 84.4% and 86.9%( P >0.05),respectively.The incidence of side effects in group A and B was 20.0% and 46.7%( P < 0.01 ),respectively.Conclusions:One week triple therapy consisting of famotidine,low dose of furozolidonum and amoxicillin achives a high cure rate of Hp.This new treatment regimen is effective and simple with lower cost and shorter treatment duration.