颈动脉粥样斑块与可溶性血管细胞粘附分子-1的关系

Relationship between carotid atherosclerosis and soluble vascular cell adhesion molecular-1

目的 探讨血清可溶性血管细胞粘附分子 1(sVCAM 1)浓度与颈动脉粥样斑块形成之间的临床关系。 方法 6 4例患者根据颈动脉超声的结果分为斑块组和健康对照组 ,通过酶联免疫吸附法测定血清sVCAM 1浓度以及血清总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)等血脂指标 ,并进行统计学分析。 结果 斑块组患者的血清sVCAM 1、TC和LDL C明显高于健康对照组 (P <0 0 5 ) ,多斑块组患者的sVCAM 1又明显高于单斑块组 (P <0 0 5 ) ,与主要血脂指标尤其是LDL C的变化相一致。 结论 脂代谢异常是颈动脉粥样斑块形成的主要危险因素 ,且在颈动脉粥样斑块的形成过程中又常伴随着血清sVCAM 1水平的升高。VCAM

Objective To study the clinical relationship between the serum level of soluble vascular cell adhesion molecular 1(sVCAM 1) and carotid artery atherosclerosis (CAA). Methods Forty two patients with CAA and 22 controls were investigated in the study. The serum levels of TC, TG, LDL C and HDL C were measured in both groups. And their serum sVCAM 1 was measured by ELISA. Results The serum level of sVCAM 1 of the patients was significantly higher than that of controls and the patients LDL C and TC were higer than controls as well. Conclusions Hypercholesterolemia is one of the main risk factors in the progression of carotid plaque. VCAM 1,as a mediator of inflammation,may involve in the mode of progression of atherosclerosis.