摘要
目的 :观察含羟基喜树碱 (HCPT)联合化疗方案治疗晚期消化系统恶性肿瘤的疗效及毒副作用。方法 :使用HCPT 6mg/m2 /d维持 4～ 6小时d1～ 10联合PLF、ELF、PPF、PAF等化疗方案治疗晚期消化系统恶性肿瘤 49例 ,其中胃癌 19例 ,结肠癌 15例 ,食管癌 11例 ,胰腺癌 4例。结果 :有效率 (RR)分别为胃癌 5 7.9% ,结肠癌 46 .7% ,食管癌 5 3.1% ,胰腺癌 5 0 .0 % ;CR 2例 ,PR 2 4例 ,NC 15例 ,PD 8例 ;总有效率 5 3.1%。毒性反应 :部分患者伴有轻度的恶心呕吐、白细胞减少、口腔粘膜炎等。结论 :治疗晚期消化系统恶性肿瘤 ,在常用的化疗方案基础上用HCPT ,具有毒性小 ,耐受性好 ,疗效高的特点 ,值得进一步推广应用。
Objective:To observe the efficacy and toxicity of hydroxycamptothecin(HCPT) combined chemotherapy in the treatment of the patients with digestive system malignant tumor. Methods: 49 cases with digestive system malignant tumor were treated with HCPT 6mg/m 2 /d iv gtt ,maintaining 4～6h,d1～10, combined with PLF,ELF,PPF,and PAF. Results:The total remission rate(CR+PR)was 53.1%,with CR 2 cases,PR 24 cases,NC 15 cases and PD 8 cases.The major toxicity were mild nausea, vomiting,neucopenia,nucositis and so on.Conclusion: HCPT was added to common chemothrapy in the treatment of advanced digestive system malignant tumor,this method is characterized by small toxicity,good toleration,and high efficacy.
出处
《四川肿瘤防治》
2002年第1期10-11,共2页
Sichuan Journal of Cancer Control
关键词
羟基喜树碱
肿瘤
消化系统
联合化疗
晚期
Hydroxycamptothecin
Malignant tumor
Digestive system
Combined chemotherapy
