摘要
目的 :观察国产胸腺五肽 (TP 5 )的疗效和不良反应。方法 :在化疗的肿瘤患者中采用双盲随机对照和单盲随机对照临床研究。结果 :化疗可导致自然杀伤 (NK)细胞活性和白介素Ⅱ (IL 2 )活性以及CD+ 4/CD+ 8比值下降 ,而TP - 5可明显改善化疗所致的NK细胞活性和IL 2活性以及CD+ 4/CD+ 8比值下降。各组免疫综合疗效评价 ,双盲组中TP 5组有效率为 14/15 (93.33% ) ,安慰剂组有效率为 1/15 (6 .6 7% )。单盲组中TP - 5组有效率为 2 4/2 7(88.80 % ) ,阳性对照组有效率为 4/2 5 (16 .0 0 % ) ,经统计学处理 ,TP 5组与安慰剂组及阳性对照组之间有极显著性差异 (P <0 .0 1)。TP - 5组 42例患者中连续应用 2 8天 ,除有 14/4 2的局部疼痛 ,7/4 2的注射处局部硬结外未观察到其他不良反应。结论 :TP - 5在化疗中可使患者机体免疫功能下降的情况得到改善 ,可作为肿瘤化疗中有价值的免疫调节药物应用。
Objective: To evaluate the efficacy and tolerance of domestic thymopentin(TP-5)in cancer patients taking chemotherapy.Methods: The double-blind single-bling control and randomized trials were conducted in 82 cancer patients taking chemotherapy. Results: The activity of interleukin-2(IL-2)and natural killer cell(NK)and the ratio of CD +_4/CD +_8 were decreased during chemotherapy course,but these changes showed significantly improved by using TP-5. Immunization response rate of TP-5 group patients was significantly higher than that of control group [The double-blind trial:TP-5 group:93.33%(14/15) vs control group 6.67%(1/15),( P <0.01);the single-blind trial:TP-5 group:88.8%(24/27)vs control group:16.0%(4/25),( P <0.01)].Conclusion:Immunologic function of cancer patients under chemotherapy could be improved by TP-5 therapy and it may be used as immunomodulatory agent during chemotherapy course.
出处
《四川肿瘤防治》
2002年第1期12-14,20,共4页
Sichuan Journal of Cancer Control
