草酸铂与5-氟脲嘧啶联合介入治疗结直肠癌肝转移

Interventional therapy of colorectal cancer with liver metastasis

目的 比较应用草酸铂与 5 -氟脲嘧啶 (5 -Fu)联合的介入治疗方案与单用 5 -Fu介入治疗方案对结直肠癌术后多发性肝转移癌患者的疗效及副作用。方法 观察组 (2 1例 )应用草酸铂 + 5 -Fu肝动脉灌注化疗 +表阿霉素与碘油乳剂栓塞肝动脉。对照组 (3 0例 )术中应用 5 -Fu肝动脉灌注化疗 +表阿霉素与碘油乳剂栓塞肝动脉。两组均以每 4周为 1周期 ,重复 2～ 4周期 ,客观疗效与毒性反应按WHO标准进行评价。结果 观察组、对照组客观疗效(CR +PR)分别为 5 7%及 40 % (P <0 0 1) ,中位生存期观察组 13 0个月 ,对照组 11 6个月 ,白细胞减少、恶心、呕吐、腹痛、发热等副作用两组差异无显著性。观察组有 4例出现外周神经毒性反应。结论 草酸铂与 5 -Fu联合用药介入治疗结直肠癌多发性肝转移的治疗效果优于 5 -Fu单一用药。

Objective To compare the effect and side effect of 5-Fu combined with eloxatin and 5-Fu in interventional therapy of colorectal cancer with to the liver metastasis after surgical operation. Methods Group A(21 cases):eloxatin+5-Fu was used for infusion chemotherapy and epirubicin mixed with lipiodol for embolization chemotherapy through proper hepatic artery. Group B(30 cases): 5-Fu infusion chemotherapy and epirubicin mixed with lipiodol for embolization two to four-week courses were initiated. WHO standard was used to evaluate objective effect and toxic effect. Results The objective treatment effect, (CR+PR) is 57% in group A and 4% in group B( P <0 01). Median survival was 13 0 months in group A, and 11 6 months in group B. Side effects such as neutropenia, nausea, vomiting, abdominal pain and fever were found in both groups without significant difference. Four patients had peripheral never toxicity in group A. Conclusion The regimen of eloxatin combined with 5-Fu is superior to 5-Fu alone in interventional therapy of colorectal cancer with liver metastasis.