掺铝β-磷酸三钙及掺锶β-磷酸三钙植入兔骨缺损区形态及组织学观察

A histological study on experimental implantation of β-tricalcium phosphate in rabbit mandible

目的 :探索磷酸钙陶瓷的化学成份、结晶相、结构形态等材料学因素与降解的关系。方法 :掺杂磷酸钙陶瓷 ( β TCPA、β TCPs)植入兔颌骨人工缺损区后观察X线片 ,横截面面积测量、光镜、电镜及能谱分析的变化。结果 :2 4周时 β TCPA 吸收率为 2 2 % ,β TCPS 为 2 8%和 β TCP为 40 %。 4周时在下颌骨和种植体之间有新骨形成 ,在 12～ 2 4周时新骨形成更明显 ,未发现炎症反应 ,界面的Ca、P和S的相对含量随时间而变化。结论 :β TCPA 和 β TCPs在组织中的降解速度较 β TCP慢 ,但其具有良好的生物相容性 ,对骨缺损的修复有较大的临床应用潜力。

砄bjective:To study the biocompatability and absorption of β tricalcium phosphate doped A10 (β TCP A) and β tricalcium phosphate doped SrO (β TCPs) in the implantation into mandible.Methods:Pieces of β TCP A,β TCPs or β TCP (β tricalcium phosphate) in the size of 10 mm×3 mm× 2.5 mm were implanted into the defects of mandible in 48 rabbits.The specimens were obtained 2,4,12 and 24 weeks after operation respectively,measured for size and observed morphologically, the content of Ca,P and S in the specimens was measured with EDAX.Results:The absorption (%) of β TCP A,β TCPs and β TCP in 24 weeks was 22,28 and 40 respectively.Bone formation was found in the interface between the mandible and materials in 4 weeks and the amount of new bone in the materials increased in 12～24 weeks.No inflammation was found.The amount of Ca,P and S in the materials was close to that in the mandible of rabbit in 24 weeks.Conclusion:β TCP A and β TCPs are biocompatable for implantation into bone deffect.